Completed Research Studies

ASSENT 2 Trial 1998

 Single-bolus tencteplase compared with front-loaded alteplase in acute myocardial infarction.

LIMIT AMI 1999

A randomized, controlled, double-blind trial of the safety and efficacy of Anto-CD18 antibody in patients with acute MI.

ASSENT 3 Trial 2000

Thrombolytic with heparin, low molecular weight heparin or 2B3A inhibitor.

N/A 

Prospective study of the availability of Lipoprotein subclass results in the process of care, phase 3. 2001

N/A

 IMPACT 2001

Study to evaluate the impact of medical subspeciality on patient compliance to treatment. 

 CRISP 2001

Single arm open lable study of Cervistatin. 

RESPOND 2002 

Study to evaluate the efficacy and safety of combination of amlodipine/atorvastatin. 

 EASE 2002

Study to evaluate the safety and efficacy of ezetimibe when added to ongoing therapy with a statin vs stating therapy alone.  

 VICTORY 2003

Study to evaluate the safety and efficacy of ezetimibe/simvastatin combination vs atorvastatin in patients with hypercholesterolemia. 

 EZTS44, 2003

Study to evaluate the safety and efficacy of ezetimibe/simvastatin combination vs atorvastatin with hypercholesterolemia 

 ARISE 2003

Study to evaluate the safety and efficacy for a vascular protectant in patients with acute coronary syndrome.                 

 MERCK 055, 2004

Study to evaluate the safety and efficacy of ezetimibe/simvastatin vs rosuvastatin. 

 GE Health Care (Amersham) - WOMENS’S STUDY 2004

A Multi Center, Prospective, Randomized Study to Establish the Optimal Method for Detection of CAD Risk in Women at an Intermediate High Pre-Test Likelihood of CAD. 

 RESTORE-US 2004

Open label study of the effectiveness of CRT in subjects diagnosed with HF-induced conduction disturbances and ventricular dysynchrony.

 CASPER 2005

Study for controlled assessment of once-daily COREG-CR vs twice daily Coreg immediate release on measures of compliance and quality of life.  

 ATHENA 2005

Study to assess efficacy of dronedarone for the prevention of cardiovascular hospitalization or death from any cause in patients with atrial fibrillation. 

 OMNI 2005

Device data collection to evaluate the effectiveness of pacemaker utilization  

 RELY 2006

Study to evaluate long term anticoagulant therapy comparing dabigatran vs warfarin in subjects with persistent or chronic atrial fibrillation.  

 MK653 2007

Sc-PRAVA-06-02: Pravastatin vs Pravastatin/Fenofibrate Phase 3 study to evaluate the safety and efficacy of daily administration. 

 DIONYSOS 2007

Amiodarone vs Dronedarone randomized double blind trial to evaluate the efficacy and safety for the maintenance of sinus rhythm in patients with atrial fibrillation.  

 CRESCENDO 2007

Metabolic study to reduce risk factor for coronary heart disease patients 

 CG107, 2007

Evaluation of Plavix in conjunction with Proton Pump Inhibitors to identify the decrease in gastrointestinal symptoms.  

 Johnson &Johnson - ROCKET 2008

A Prospective, Randomized, Double-Blind, Double Dummy, Parallel-Group, Multi-Center, Event-Driven, Non-Inferiority Study Comparing the Efficacy and Safety of Once-Daily Oral Rivaroxaban (BAY 59-7939) with Adjusted-Dose Oral Warfarin for the Prevention of Stroke and Non-Central Nervous System Systemic Embolism in Subjects with Non-Valvular Atrial Fibrillation.  

 CV-Therapeutics – CVT 3041, 2008

An Open-Label, Mulit-Center Study Evaluating the Validity, Reliability, and Responsiveness of a New Women’s Ischemia Symptom Questionnaire in Women with Chronic Angina Treated with Ranolazine Extended-Release Tablets 

 Roche CV M&M – NC20971 RG 2008

: Roche Sample Respository Research Project in conjunction with protocol NC20971. A phase 3, double-blind, randomized placebo-controlled study, to evaluate the effects of RO4607381 on cardiovascular (CV) risk in stable CHD patients, with a documented recent Acute Coronary Syndrome (ACS)  

 Daiichi Sankyo ENGAGE – DU176b-C-U301, 2008

A Phase 3, Randomized, Double-blind, Double-Dummy, Parallel Group, Mulit-Center, Multi-National Study for Evaluation of Efficacy and Safety of DU-176B vs. Warfarin in Subjects with Atrial Fibrillation – Effective aNticoaGulation with factor xA next Generation in Atrial Fibrillation (ENGAGE AF – TIMI48). 

 Johnson & Johnson Atlas RIVAROX ACS 3001, 2008

A Randomized, Double-Blind, Placebo-Controlled, Event-Driven Multicenter Study to Evaluate the Efficacy and Safety of Rivaroxaban in Subjects With a Recent Acute Coronary Syndrome.  

 Integrium Resverlogix 2010

A Phase II, Multi-Center, Double-Blind, Randomized, Parallel Group, Placebo-Controlled Clinical Trial For Dose-Finding And Safety Study Of RVX000222 In Subjects With Stable Coronary Artery Disease.  

 Bristol Myers Squibb, Pfizer Inc. CV185068 APPRISE-2, 2010

A Phase 3, Randomized, Double Blind, Evaluation of the Safety and Efficacy of Apixaban in Subjects with a Recent Acute Coronary Syndrome 

 NovartisCLCZ696B2314, 2010

A multicenter, randomized, double-blind, parallel group, active-controlled study to evaluate the efficacy and safety of LCZ696B compared to enalapril on morbidity and mortality in patients with chronic heart failure and reduced ejection fraction.